Stereochemical control in microbial reduction.

Environmental factors that control microbial perchlorate reduction.

As part of a study to elucidate the environmental parameters that control microbial perchlorate respiration, we investigated the reduction of perchlorate by the dissimilatory perchlorate reducer Dechlorosoma suillum under a diverse set of environmental conditions. Our results demonstrated that perchlorate reduction by D. suillum only occurred under anaerobic conditions in the presence of perchl...

Stereochemical control of DNA biosynthesis.

Stereochemical control of DNA biosynthesis was studied using several DNA-synthesizing complexes containing, in each case, a single substitution of a 2'-deoxy-D-nucleotide residue by an enantiomeric L-nucleotide residue in a DNA chain (either in the primer or in the template) as well as 2'-deoxy-L-ribonucleoside 5'-triphosphates (L-dNTPs) as substrates. Three template-dependent DNA polymerases w...

Stereochemical control of peptide folding.

Stereochemically constrained amino acid residues that strongly favour specific backbone conformations may be used to nucleate and stabilize specific secondary structures in designed peptides. An overview of the use of alphaalpha-dialkyl amino acids in stabilizing helical structures in synthetic peptides is presented, with an emphasis on work carried out in the authors laboratory. Alpha-aminoiso...

Stereochemical Control of Yeast Reduction of α-Keto Esters in an Organic Solvent

Stereochemical Control in Microwave Stimulated Acylation Reactions

There is an extensive body of literature reporting rate enhancements when organic reactions are carried out in the presence of a microwave field. Much of this relates to reactions performed in pressure vessels where the rate enhancement observed occurs as a function of the elevated boiling points that result from the autothermal pressure within the sealed system. An alternative approach has bee...